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Page 1
Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling.
Gamez-Belmonte R, Mahapatro M, Erkert L, Gonzalez-Acera M, Naschberger E, Yu Y, Tena-Garitaonaindia M, Patankar JV, Wagner Y, Podstawa E, Schödel L, Bubeck M, Neurath MF, Stürzl M, Becker C. Gamez-Belmonte R, et al. Gut. 2023 Jun;72(6):1155-1166. doi: 10.1136/gutjnl-2022-327323. Epub 2022 Oct 19. Gut. 2023. PMID: 36261293
Psen1-deficient mice developed only small tumours and human cancer cell lines deficient in Psen1 had a reduced tumourigenicity. ...CONCLUSIONS: Psen1 drives tumour development by increasing EGFR signalling via NOTCH1 processing, and by activating the C …
Psen1-deficient mice developed only small tumours and human cancer cell lines deficient in Psen1 had a reduced tumourigenicity …
A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis.
Li Y, Zhang T, Zhou Y, Sun Y, Cao Y, Chang X, Zhu Y, Han X. Li Y, et al. Sci Rep. 2016 Nov 2;6:36136. doi: 10.1038/srep36136. Sci Rep. 2016. PMID: 27804997 Free PMC article.
We found that the protein levels of presenilins (PSEN1 and PSEN2), and NOTCH1 were decreased in INS-1 cells after treatment with increased concentrations of glucose, whereas no significant alteration of mRNA level of Notch1 was observed. Targeting of miR-375, …
We found that the protein levels of presenilins (PSEN1 and PSEN2), and NOTCH1 were decreased in INS-1 cells after treatment wi …
Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease.
Nomura T. Nomura T. Front Immunol. 2020 May 20;11:847. doi: 10.3389/fimmu.2020.00847. eCollection 2020. Front Immunol. 2020. PMID: 32508815 Free PMC article. Review.
Although its precise pathogenic mechanisms remain unknown, I herein emphasize the importance of the following three recent discoveries in the pathogenesis of HS: First, heterozygous loss-of-function mutations in the genes encoding gamma-secretase, including NCSTN, PSENEN, and …
Although its precise pathogenic mechanisms remain unknown, I herein emphasize the importance of the following three recent discoveries in th …
miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1.
Xin X, Duan L, Yang H, Yu H, Bao Y, Jia D, Wu N, Qiao Y. Xin X, et al. Environ Toxicol. 2022 Apr;37(4):741-753. doi: 10.1002/tox.23439. Epub 2021 Dec 12. Environ Toxicol. 2022. PMID: 34897970
Mechanistically, it was further revealed that miR-141-3p could specifically bind to presenilin 1 (PSEN1) 3'UTR, and upregulating miR-141-3p levels reduced the expression of PSEN1, thereby inhibiting the activation of the Notch1/PTEN/AKT pathway. ...In conclus …
Mechanistically, it was further revealed that miR-141-3p could specifically bind to presenilin 1 (PSEN1) 3'UTR, and upregulating miR- …
Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.
Nornes S, Newman M, Wells S, Verdile G, Martins RN, Lardelli M. Nornes S, et al. Exp Cell Res. 2009 Oct 1;315(16):2791-801. doi: 10.1016/j.yexcr.2009.06.023. Epub 2009 Jun 27. Exp Cell Res. 2009. PMID: 19563801
PSEN1 has been shown to be crucial for proteolytic cleavage of Notch in developing animal embryos. Mouse embryos lacking Psen1 function show disturbed neurogenesis and somite formation, resembling Notch pathway mutants. ...
PSEN1 has been shown to be crucial for proteolytic cleavage of Notch in developing animal embryos. Mouse embryos lacking Psen1 …
Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Berezovska O, Jack C, Deng A, Gastineau N, Rebeck GW, Hyman BT. Berezovska O, et al. J Biol Chem. 2001 Aug 10;276(32):30018-23. doi: 10.1074/jbc.M008268200. Epub 2001 Jun 14. J Biol Chem. 2001. PMID: 11408475 Free article.
Similar gamma-secretase processing occurs in another transmembrane protein, Notch1, releasing a potent signaling molecule, the Notch C-terminal domain. ...Overexpressing human APP (APP(695Sw)) in neurons leads to a decrease in endogenous Notch1 signal transduction, …
Similar gamma-secretase processing occurs in another transmembrane protein, Notch1, releasing a potent signaling molecule, the Notch …
A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling.
Zhang S, Cai F, Wu Y, Bozorgmehr T, Wang Z, Zhang S, Huang D, Guo J, Shen L, Rankin C, Tang B, Song W. Zhang S, et al. Mol Psychiatry. 2020 Mar;25(3):603-613. doi: 10.1038/s41380-018-0101-x. Epub 2018 Jun 18. Mol Psychiatry. 2020. PMID: 29915376
FAD-associated mutant PSEN1 proteins have been shown to affect APP processing and Abeta generation and inhibit Notch1 cleavage and Notch signaling. ...However, this mutation did not affect Notch1 cleavage and Notch signaling in vitro and in vivo. Taken togeth …
FAD-associated mutant PSEN1 proteins have been shown to affect APP processing and Abeta generation and inhibit Notch1 cleavage …
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Berezovska O, et al. J Neurochem. 2000 Aug;75(2):583-93. doi: 10.1046/j.1471-4159.2000.0750583.x. J Neurochem. 2000. PMID: 10899933 Free article.
We developed an assay to monitor ligand-induced Notch1 proteolysis and nuclear translocation in individual cells : Treatment of full-length Notch1-enhanced green fluorescent protein-transfected Chinese hamster ovary (CHO) cells with a soluble preclustered form of th …
We developed an assay to monitor ligand-induced Notch1 proteolysis and nuclear translocation in individual cells : Treatment of full- …
Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.
Hernandez-Sapiens MA, Reza-Zaldívar EE, Márquez-Aguirre AL, Gómez-Pinedo U, Matias-Guiu J, Cevallos RR, Mateos-Díaz JC, Sánchez-González VJ, Canales-Aguirre AA. Hernandez-Sapiens MA, et al. Neural Regen Res. 2022 Jan;17(1):31-37. doi: 10.4103/1673-5374.313016. Neural Regen Res. 2022. PMID: 34100423 Free PMC article.
The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. ...This review focuses on the neur …
The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 ca …
CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain.
Monti N, Cavallaro RA, Stoccoro A, Nicolia V, Scarpa S, Kovacs GG, Fiorenza MT, Lucarelli M, Aronica E, Ferrer I, Coppedè F, Troen AM, Fuso A. Monti N, et al. Epigenetics. 2020 Aug;15(8):781-799. doi: 10.1080/15592294.2020.1722917. Epub 2020 Feb 5. Epigenetics. 2020. PMID: 32019393 Free PMC article.
Other substrates of the gamma-secretase, such as E-cadherin and Notch1, are involved in neurodevelopment and haematopoiesis. Gene-specific DNA methylation influences PSEN1 expression in AD animal models. ...PSEN1 methylation in blood DNA was significantly low …
Other substrates of the gamma-secretase, such as E-cadherin and Notch1, are involved in neurodevelopment and haematopoiesis. Gene-spe …
68 results